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The entire spectrum of peptide uptake has been revealed


Peptide uptake systems via proton-coupled oligopeptide transporter (POT) family members are conserved across all organisms from microorganisms to higher animals and plants and are important for acquiring nitrogen resources with high efficiency. POT family proteins are characterised by their substrate multispecificity that one transporter can recognise as many as 8,400 types of di/tripeptides as substrates. This unique characteristic enables certain types of drugs to be absorbed by the human intestine and kidney. Thus, the substrate multispecificity of POT family proteins has been analysed for certain specific drugs and prodrugs. However, the entire spectrum of substrate preference by POT family proteins has not been elucidated. A research group consisting of Drs. K. Ito, Y. Yoshikawa and Y. Kawarasaki, School of Food and Nutritional Sciences faculties, and their colleagues elucidated the substrate multispecificity of a POT protein. This information is of interest in various fields of science and industry including drug development, nutrition, stock breeding and fermentation.

K. Ito, A. Hikida, S. Kawai, Vu T.T. Lan, T. Motoyama, S. Kitagawa, Y. Yoshikawa, R. Kato, Y. Kawarasaki. Analysing the substrate multispecificity of a proton-coupled oligopeptide transporter using a dipeptide library.
Nature Communications 2013 doi: 10.1038/ncomms3502.